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KMID : 0370019930070000077
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Chung-Ang Journal of Pharmacal Sciences
1993 Volume.7 No. 0 p.77 ~ p.88
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Studies on the immune response of thymopentin
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Abstract
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It was studied on the immune response of thymopentin in order to expand the clinical application of this. The experimental results are as follows.
1. Thymopentin of 3 to 10㎍/ml in vitro showed the mitogenic effect of spleen cells and Con A-stimulated spleen and thymus cells, but not lipopolysaccaride(LPS) stimulated spleen and tumorcells.
2. Thymopentin significantly decreased the T-independent B cells at S.C. adminstration of 100mg/kg for 5 days, in case of pretreated group, the potent inhibition of the B-cells were observed at doses of 25.50 100mg/kg in mice.
3. Thymopentin stimulated the response of delayed type hypersensitivity, SRBC-induced footpad swelling and oxazolone-induced contact dermatitis in mice.
From the above results, it is shown that thypopentin decreased the B_E-cells, and stimulates the T_D-cells in mice.
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